男，医学博士，博士生导师

安徽医科大学二级教授，安徽省首批学术和技术带头人，中华医学会“新中国六十年医疗卫生事业杰出贡献奖”获得者，获省级科学技术二等奖一项，三等奖4项，《安徽预防医学杂志》编委会主任，《安徽医科大学学报》、《中华疾病控制杂志》和《职业卫生与应急救援》副主编，担任全国医药高等院校规划教材《卫生学》（临床医学本科，第8版、第9版）主编、全国医药高等院校规划教材《预防医学》（护理本科，第1版）主编、全国医药高等院校规划教材《职业卫生与职业医学》（预防医学本科，第8版）副主编，全国住院医师规范化培训规划教材《预防医学》（第1版、第2版）主编

学术职务：中华预防医学会常务理事、安徽省预防医学会会长

研究方向：皮肤毒理;职业毒理

主要科研项目：

① 国家自然科学基金面上项目，名称：血管内皮细胞活化介导三氯乙烯免疫性肾损伤及其机制（批准号：82173494），主持，起止年月：2022/01-2025/12;

② 国家自然科学基金面上项目，名称：补体膜攻击复合物C5b-9介导三氯乙烯免疫性肾小管损伤机制研究（批准号：81874259），主持，起止年月：2019/01-2022/12;

③ 国家自然科学基金面上项目，名称：细胞内补体激活介导的足细胞损伤在三氯乙烯免疫性肾损害中作用（批准号：81673141）, 主持，起止年月：2017/01-2020/12；

④ 国家自然科学基金面上项目，名称：补体及其介导的药物特异性T细胞在重症药疹肝肾损伤中的作用（批准号：81371730），主持，起止年月：2014/01-2017/12；

⑤ 国家自然科学基金面上项目，名称：三氯乙烯致免疫性多脏器损伤及其机制研究（批准号：30872147），主持，起止年月：2009/01-2011/12；

⑥ 国家自然科学基金面上项目，名称：三氯乙烯药疹样皮炎的免疫反应信号放大机制研究（批准号：30671787），主持，起止年月：2007/01-2009/12；

⑦ 国家自然科学基金面上项目，名称：氯乙烯诱导角质形成细胞凋亡中氧化应激、mtDNA突变及线粒体损伤的研究（批准号：30471469），主持，起止年月：2005/01-2007/12

主讲课程：本科生《职业卫生与职业医学》

发表论文情况：

1.Qirui Bai, Chen You, Zhuohui Qin, Qixing Zhu, Haibo Xie. mTORC1-mediated inhibition of AMBRA1/PINK1/Parkin-dependent mitophagy contributes to renal podocyte injury in trichloroethylene-sensitized mice. Toxicol Appl Pharmacol, 2026  (SCI, 中科院二区，通讯作者)

2. Chen You, Zhuohui Qin, Rui Li, Jian Chen, Qixing Zhu, Haibo Xie. Serum amyloid A1 activates the NLRP3 inffammasome via TLR2 to mediate trichloroethylene-induced immune kidney injury. Arch Biochem Biophys, 2026 (SCI, 中科院二区，通讯作者)

3. Haibo Xie, Jingyi Zhao, Jian Chen, Rui Li, Hui Li, Qifeng Wu, Chen You, Jiaxiang Zhang, Bo Liang, Qixing Zhu. MPTP controls the release of mtDNA and induces endothelial cell PANoptosis in trichloroethylene-induced immune kidney injury. Eur J Pharmacol 2025 (SCI, 中科院二区，通讯作者)

4. Chen J, You C, Xie H, Zhu Q. Mitochondrial RNA in Inflammation, Int J Biol Sci 2025 (SCI, 中科院一区，通讯作者)

5. Haibo Xie, Bo Liang, Jingyi Zhao, Chen You, Qirui Bai, Rui Li, Jian Chen, Pengcheng Zhou, Luolun Dong, Ruixuan Cheng, Jiaxiang Zhang, Qixing Zhu. Target complement factor H / serum amyloid a signaling in trichloroethylene-induced immune kidney injury. Ecotoxicol Environ Saf. 2025 (SCI, 中科院一区，通讯作者)

6. Haibo Xie, Yuansheng Duan, Pengcheng Zhou, Yu Li, Jihong Gao, Ruixuan Cheng, Zhibing Liu, Jiaxiang Zhang, Qixing Zhu. TNF-α-downregulated SIRT1 regulates mitochondrial-autophagy and apoptosis in renal vascular endothelial cells involved in trichloroethylene-induced immune kidney injury. Int Immunopharmacol 2024 (SCI, 中科院二区，通讯作者)

7. Liu Z, Ma J, Zuo X, Zhang X, Xie H, Wang F, Wu C, Zhang J, Zhu Q. IP3R-dependent mitochondrial dysfunction mediates C5b-9-induced ferroptosis in trichloroethylene-caused immune kidney injury. Front Immunol, 2023 (SCI, 中科院二区，通讯作者)

8. Zhang X, Xie H, Liu Z, Zhang J, Deng L, Wu Q, Duan Y, Wang F, Wu C, Zhu Q. HMGB 1 acetylation mediates trichloroethylene-induced immune kidney injury by facilitating endothelial cell-podocyte communication. Ecotoxicol Environ Saf, 2023(SCI, 中科院一区，通讯作者)

9. Zhou S, Wang Z, Gao L, Chen M, Duan Y, Zhou P, Liu Z, Wu C, Zhang J, Zhu Q. C5a/C5aR1 axis as a key driver promotes epithelial-to-mesenchymal transition in airway epithelial cells in silica nanoparticles-induced pulmonary fibrosis. Int Immunopharmacol, 2023(SCI, 中科院二区，通讯作者)

10. Zhang X, Duan Y, Ma J, Liu Z, Ding Y, Xie H, Peng J, WangF, Zhang J, Zhu Q. Trichloroethylene induces immune renal tubular injury through SIRT 1/HSP 70/TLR 4 pathway in BALBc mice. Int Immunopharmacol, 2022(SCI, 中科院二区，通讯作者)

11. Xie H, Peng J, Zhang X, Deng L, Ding Y, Zuo X, Wang F, Wu Y, Zhang J, Zhu Q. Effects of mitochondrial reactive oxygen species-induced NLRP3 inflammasome activation on trichloroethylene-mediated kidney immune injury. Ecotoxicol Environ Saf, 2022(SCI, 中科院一区，通讯作者)

12.Liu Z, Ma J, Zuo X, Zhang X, Hong Y, Cai S, Huang H, Wang F, Wu C, Zhang J, Zhu Q. C5b-9 mediates ferroptosis of tubular epithelial cells in trichloroethylene-sensitization mice. Ecotoxicol Environ Saf, 2022(SCI, 中科院二区，通讯作者)

13.Zuo X, Liu Z, Ma J, Ding Y, Cai S, Wu C, Zhang J, Zhu Q. Wnt 5a mediated inflammatory injury of renal tubular epithelial cells dependent on calcium signaling pathway in Trichloroethylene sensitized mice. Ecotoxicol Environ Saf, 2022(SCI, 中科院一区，通讯作者)

14.Wang F, Huang M, Wang Y, Hong Y, Zang D, Yang C, Wu C, Zhu Q. Membrane Attack Complex C5b-9 Promotes Renal Tubular Epithelial Cell Pyroptosis in Trichloroethylene-Sensitized Mice. Front Pharmacol, 2022(SCI, 中科院二区，通讯作者)

15. Zhang JX, Yang Y, Huang H, Xie HB, Huang M, Jiang W, Ding BW, Zhu QX. TNF-α/TNFR1 regulates the polarization of Kupffer cells to mediate trichloroethylene-induced liver injury. Ecotoxicol Environ Saf, 2022(SCI, 中科院一区，通讯作者)

16. Ma J, Liu Z, Zhou S, Chen M, Gao L, Zuo X, Zhang X, Zhang J, Zhu Q. Renal tubular in TCE-sensitization-induced immune kidney injury: Role of mitochondrial DNA in activating the cGAS-STING signaling pathway. Int Immunopharmacol, 2022 (SCI, 中科院二区，通讯作者)

17.Wang F, Dai Y, Huang M, Zhang C, Huang L, Wang H, Ye L, Wu Q, Zhang X, Zhu Q. Glomerular Damage in Trichloroethylene-Sensitized Mice: Targeting Cathepsin L-Induced Hyperactive mTOR Signaling. Front Pharmacol. 2021(SCI, 中科院二区，通讯作者)

18. Xie H, Yang L, Yang Y, Jiang W, Wang X, Huang M, Zhang J, Zhu Q. C5b-9 membrane attack complex activated NLRP3 inflammasome mediates renal tubular immune injury in trichloroethylene sensitized mice. Ecotoxicol Environ Saf, 2021(SCI, 中科院二区，通讯作者)

19.Xie H, Wang H, Wu Q, Peng J, Huang H, Wang Y, Huang M, Jiang W, Yang Y, Zhang X, Zhang J, Zhu Q. Endothelin-1/Endothelin Receptor Type A-Angiopoietins/Tie-2 Pathway in Regulating the Cross Talk Between Glomerular Endothelial Cells and Podocytes in Trichloroethylene-Induced Renal Immune Injury. J Inflamm Res,2021(SCI, 中科院二区，通讯作者)